Formation of Golgi-Derived Active Zone Precursor Vesicles
نویسندگان
چکیده
منابع مشابه
Formation of Golgi-derived active zone precursor vesicles.
Vesicular trafficking of presynaptic and postsynaptic components is emerging as a general cellular mechanism for the delivery of scaffold proteins, ion channels, and receptors to nascent and mature synapses. However, the molecular mechanisms leading to the selection of cargos and their differential transport to subneuronal compartments are not well understood, in part because of the mixing of c...
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ELECTRON MICROSCOPIC STUDY OF THE GOLGI ZONE OF THE RAT SPERMATIDS REVEALED TWO MAIN TYPES OF VESICULAR STRUCTURES: flat vesicles generally accumulated in stacks and spheroidal vesicles of various sizes. The Golgi zone of young spermatids showed a predominance of flat vesicles and small spherical vesicles, while the "residual" Golgi zone of the maturing spermatids displayed an increased number ...
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Clathrin has previously been implicated in Drosophila male fertility and spermatid individualization. To understand further the role of membrane transport in this process, we analyzed the phenotypes of mutations in Drosophila auxilin (aux), a regulator of clathrin function, in spermatogenesis. Like partial loss-of-function Clathrin heavy chain (Chc) mutants, aux mutant males are sterile and pro...
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In this study, we examined the subcellular distribution and functions of LIMK1 in developing neurons. Confocal microscopy, subcellular fractionation, and expression of several epitope-tagged LIMK1 constructs revealed that LIMK1 is enriched in the Golgi apparatus and growth cones, with the LIM domain required for Golgi localization and the PDZ domain for its presence at neuritic tips. Overexpres...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2012
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.0195-12.2012